Before taking Viagra
Do not take Viagra if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket). Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking Viagra with a nitrate medicine can cause a sudden and serious decrease in blood pressure.
Viagra is a vasodilator and it is extensively metabolized by CYP3A4 and 2C9 liver enzymes. Therefore, combining Viagra with other vasodilators will increase the incidence of hypotension, and CYP3A4 or 2C9 inhibitors will increase the blood levels of Viagra.
Mechanism of Action
Viagra is a selective phosphodiesterase type 5 (PDE5) inhibitor. PDE5 is responsible for breaking down cyclic guanyl monophosphate (cGMP), a vasodilator produced in response to nitric oxide that is released due to sexual stimulation in the corpus cavernosum. Inhibition of PDE5 increases cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum, causing penile erection. Viagra works in response to sexual stimulation.
Will Viagra affect men fertility and sexual desire?
Viagra has absolutely no effect on men fertility and sexual desire. Viagra will not make men more lustful nor will viagra increase men sexual appetite and sexual prowess as Viagra is simply a medication for erectile dysfunction treatment.Viagra is not an aphrodisiac and will not turn men into sex maniac.
How to take Viagra
Take Viagra exactly as your doctor has prescribed. Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained in this leaflet. If you do not understand the instructions on the pack, ask your doctor or pharmacist for help.
When to take it
Take your dose of Viagra about one hour before you intend to have sex. Swallow the tablet whole with a full glass of water. The amount of time Viagra takes to start working varies from person to person, but it normally takes between half an hour and one hour. You may find Viagra takes longer to work if you take it with a heavy meal. Viagra will work only if you are sexually excited.
Can I drink alcohol alongside Viagra?
It is not advisable to drink large amounts of alcohol before taking Viagra.
What are the side-effects?
Viagra's Side effects are generally mild and brief. Viagra's most common side-effects are headache and facial flushing. Less frequently, men taking Viagra have reported indigestion, a stuffy nose and a blue tint to the vision.
What if Viagra doesn't work?
As stated Viagra works in around 80% of known cases. However, you may need to try Viagra in varying doses for it to work effectively for you. Should it not work, please consult your doctor to discuss other alternatives.
Keep this medicine where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. Keep Viagra in a cool; dry place where the temperature stays below 30°C. Do not store it or any other medicine in the bathroom or near a sink. Do not leave it in the car or on windowsills. Heat and dampness can destroy some medicines. Keep the tablets in their pack until it is time to take them. If you take your tablets out of the pack they will not keep as well.